Discordant circulating fetal DNA and subsequent cytogenetics reveal false negative, placental mosaic, and fetal mosaic cfDNA genotypes
نویسندگان
چکیده
منابع مشابه
Effect of Aspirin Consumption during Pregnancy on Fetal and Placental Weights and Histomorphometric Changes of the Fetal Stomach in Rats
Background & Objective: Due to the relevant use of aspirin to relieve pain and common symptoms of gastric ulcer and possible malicious effects on fetus, this study investigates the histomorphologic effects of aspirin on the stomach tissue in rat embryos. Materials & Methods: In this experimental study, 30 pregnant female rats were randomly divided into six groups including control group wi...
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Contents 1. Introduction 2. Gene expression for uterine proteins and nutrient transporters 2.1. Temporal and spatial changes in steroid hormone receptors in the uterus during the peri-implantation period of pregnancy 3. Pregnancy recognition 3.1. Luteotrophic versus antiluteolytic signaling for pregnancy recognition 3.2. Corpus luteum formation and regression 3.3. Pregnancy recognition signals ...
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Fetal RHD genotype detection from circulating cell-free fetal DNA in maternal plasma in non-sensitized RhD negative women.
OBJECTIVE To examine the performance of the SensiGene Fetal RHD Genotyping Laboratory Developed Test (RHD Genotyping LDT) using circulating cell-free fetal DNA (ccff DNA) extracted from maternal plasma. METHODS ccff DNA was extracted from maternal blood from non-sensitized women with singleton pregnancies in two cohorts, one with a serotype reference (11-13 weeks' gestation) and one with the ...
متن کاملCirculating fetal DNA: its origin and diagnostic potential-a review.
OBJECTIVE In contrast to the traditional teaching that the placenta forms an impermeable barrier, multiple studies show that both intact fetal cells and cell-free nucleic acids circulate freely in maternal blood. Complications of pregnancy, such as pre-eclampsia, or fetal cytogenetic abnormalities, such as trisomy 21, increase transfusion of both intact fetal cells and cell-free fetal nucleic a...
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ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2015
ISSN: 1479-5876
DOI: 10.1186/s12967-015-0569-y